{"id":11389,"date":"2022-02-08T06:42:13","date_gmt":"2022-02-08T12:42:13","guid":{"rendered":"https:\/\/leukemiarf.org\/?p=11389"},"modified":"2022-07-27T09:26:31","modified_gmt":"2022-07-27T14:26:31","slug":"discovery-broadens-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/","title":{"rendered":"Discovery Broadens Applications for CAR T-Cell Therapy"},"content":{"rendered":"\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>CAR T-cell therapy uses a patient\u2019s modified T cells to target their cancer. This therapy takes advantage of what T-cells do naturally \u2013 find and destroy invaders.<\/p>\n\n\n\n<p>While CAR T-cell therapy has been a game-changer, it is not effective at treating all types of cancer. In some cases, the engineered T cells become exhausted and stop fighting. The therapy is also less effective against solid tumors.<\/p>\n\n\n\n<p>Researchers at Children\u2019s Hospital of Los Angeles are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients. In preliminary studies, they have found that increasing the activity of a gene found in T cells makes them stronger and longer-lasting. This gene is called BCL11B.<\/p>\n\n\n\n<p>Chintan Parekh, MD, a physician-scientist in the Cancer and Blood Disease Institute at Children\u2019s Hospital Los Angeles, is leading the study.<\/p>\n\n\n\n<p>\u201cSo far, in our experiments, these modified T cells are working harder,\u201d he says. \u201cThey don\u2019t exhaust or die off as easily. They stay in the fight longer. This could eventually translate into more effective therapies for patients with resistant leukemia or solid tumors.\u201d<\/p>\n\n\n\n<p>But the potential applications don\u2019t end there. The researchers also found that this same gene instructs developing immune cells to become T cells. This means that increasing the gene in developing immune cells could encourage T cell regrowth in patients.<\/p>\n\n\n\n<p>\u201cIn patients who need a <a href=\"https:\/\/leukemiarf.org\/patients\/treatment\/options\/transplants\/\">bone marrow transplant<\/a>, for example, the chemotherapy can wipe out a patient\u2019s immune system,\u201d said Dr. Parekh. \u201cNew immune cells begin to develop from the donor marrow in a few weeks, but T cells can take months to regenerate.\u201d<\/p>\n\n\n\n<p>A lack of T cells leaves patients vulnerable to infections and at a greater risk of their leukemia relapsing. Speeding up the regrowth of T-cells could be life-changing. Dr. Parekh\u2019s preclinical studies have shown that, at least in the laboratory, increasing BCL11B does just this.<\/p>\n\n\n\n<p>Dr. Parekh\u2019s research was supported in part by the Leukemia Research Foundation in 2018. In February 2022, Dr. Parekh received a $2.3M grant from the National Institute of Allergy and Infectious Diseases to further pursue his research.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CAR T-cell therapy uses a patient\u2019s modified T cells to target their cancer. This therapy takes advantage of what T-cells do naturally \u2013 find and destroy invaders. While CAR T-cell&hellip;<\/p>\n","protected":false},"author":10,"featured_media":11390,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[50,72],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.4 (Yoast SEO v22.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Discovery Broadens Applications for CAR T-Cell Therapy<\/title>\n<meta name=\"description\" content=\"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery Broadens Applications for CAR T-Cell Therapy\" \/>\n<meta property=\"og:description\" content=\"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"Leukemia Research Foundation\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/LeukemiaResearch\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-08T12:42:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-27T14:26:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"368\" \/>\n\t<meta property=\"og:image:height\" content=\"245\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Kelsey Raftery\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Kelsey Raftery\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\"},\"author\":{\"name\":\"Kelsey Raftery\",\"@id\":\"https:\/\/leukemiarf.org\/#\/schema\/person\/6105c72674e561b3536963673c934146\"},\"headline\":\"Discovery Broadens Applications for CAR T-Cell Therapy\",\"datePublished\":\"2022-02-08T12:42:13+00:00\",\"dateModified\":\"2022-07-27T14:26:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\"},\"wordCount\":359,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/leukemiarf.org\/#organization\"},\"image\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg\",\"articleSection\":[\"News\",\"Research breakthroughs\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\",\"url\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\",\"name\":\"Discovery Broadens Applications for CAR T-Cell Therapy\",\"isPartOf\":{\"@id\":\"https:\/\/leukemiarf.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg\",\"datePublished\":\"2022-02-08T12:42:13+00:00\",\"dateModified\":\"2022-07-27T14:26:31+00:00\",\"description\":\"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.\",\"breadcrumb\":{\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage\",\"url\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg\",\"contentUrl\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg\",\"width\":368,\"height\":245},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/leukemiarf.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discovery Broadens Applications for CAR T-Cell Therapy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/leukemiarf.org\/#website\",\"url\":\"https:\/\/leukemiarf.org\/\",\"name\":\"Leukemia Research Foundation\",\"description\":\"A world without leukemia\",\"publisher\":{\"@id\":\"https:\/\/leukemiarf.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/leukemiarf.org\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/leukemiarf.org\/#organization\",\"name\":\"Leukemia Research Foundation\",\"alternateName\":\"LRF\",\"url\":\"https:\/\/leukemiarf.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/leukemiarf.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/03\/Icon_Red.png\",\"contentUrl\":\"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/03\/Icon_Red.png\",\"width\":118,\"height\":118,\"caption\":\"Leukemia Research Foundation\"},\"image\":{\"@id\":\"https:\/\/leukemiarf.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/LeukemiaResearch\",\"https:\/\/www.youtube.com\/channel\/UC923DiAUlYsTrnOtm1-rbYg\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/leukemiarf.org\/#\/schema\/person\/6105c72674e561b3536963673c934146\",\"name\":\"Kelsey Raftery\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/leukemiarf.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/1b8e3fe9a4161dac9fbf2cf71b319afc?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/1b8e3fe9a4161dac9fbf2cf71b319afc?s=96&d=mm&r=g\",\"caption\":\"Kelsey Raftery\"},\"sameAs\":[\"duncan@lrfmail.org\"],\"url\":\"https:\/\/leukemiarf.org\/news\/author\/kelseylrfmail-org\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Discovery Broadens Applications for CAR T-Cell Therapy","description":"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/","og_locale":"en_US","og_type":"article","og_title":"Discovery Broadens Applications for CAR T-Cell Therapy","og_description":"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.","og_url":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/","og_site_name":"Leukemia Research Foundation","article_publisher":"https:\/\/www.facebook.com\/LeukemiaResearch","article_published_time":"2022-02-08T12:42:13+00:00","article_modified_time":"2022-07-27T14:26:31+00:00","og_image":[{"width":368,"height":245,"url":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg","type":"image\/jpeg"}],"author":"Kelsey Raftery","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Kelsey Raftery","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#article","isPartOf":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/"},"author":{"name":"Kelsey Raftery","@id":"https:\/\/leukemiarf.org\/#\/schema\/person\/6105c72674e561b3536963673c934146"},"headline":"Discovery Broadens Applications for CAR T-Cell Therapy","datePublished":"2022-02-08T12:42:13+00:00","dateModified":"2022-07-27T14:26:31+00:00","mainEntityOfPage":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/"},"wordCount":359,"commentCount":0,"publisher":{"@id":"https:\/\/leukemiarf.org\/#organization"},"image":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg","articleSection":["News","Research breakthroughs"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/","url":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/","name":"Discovery Broadens Applications for CAR T-Cell Therapy","isPartOf":{"@id":"https:\/\/leukemiarf.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage"},"image":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg","datePublished":"2022-02-08T12:42:13+00:00","dateModified":"2022-07-27T14:26:31+00:00","description":"Researchers are investigating ways to broaden the applications for CAR T-cell therapy in leukemia patients.","breadcrumb":{"@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#primaryimage","url":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg","contentUrl":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/02\/parekh.jpg","width":368,"height":245},{"@type":"BreadcrumbList","@id":"https:\/\/leukemiarf.org\/news\/discovery-broadens-car-t-cell-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/leukemiarf.org\/"},{"@type":"ListItem","position":2,"name":"Discovery Broadens Applications for CAR T-Cell Therapy"}]},{"@type":"WebSite","@id":"https:\/\/leukemiarf.org\/#website","url":"https:\/\/leukemiarf.org\/","name":"Leukemia Research Foundation","description":"A world without leukemia","publisher":{"@id":"https:\/\/leukemiarf.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/leukemiarf.org\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/leukemiarf.org\/#organization","name":"Leukemia Research Foundation","alternateName":"LRF","url":"https:\/\/leukemiarf.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/leukemiarf.org\/#\/schema\/logo\/image\/","url":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/03\/Icon_Red.png","contentUrl":"https:\/\/leukemiarf.org\/wp-content\/uploads\/2022\/03\/Icon_Red.png","width":118,"height":118,"caption":"Leukemia Research Foundation"},"image":{"@id":"https:\/\/leukemiarf.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/LeukemiaResearch","https:\/\/www.youtube.com\/channel\/UC923DiAUlYsTrnOtm1-rbYg"]},{"@type":"Person","@id":"https:\/\/leukemiarf.org\/#\/schema\/person\/6105c72674e561b3536963673c934146","name":"Kelsey Raftery","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/leukemiarf.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/1b8e3fe9a4161dac9fbf2cf71b319afc?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1b8e3fe9a4161dac9fbf2cf71b319afc?s=96&d=mm&r=g","caption":"Kelsey Raftery"},"sameAs":["duncan@lrfmail.org"],"url":"https:\/\/leukemiarf.org\/news\/author\/kelseylrfmail-org\/"}]}},"_links":{"self":[{"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/posts\/11389"}],"collection":[{"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/comments?post=11389"}],"version-history":[{"count":3,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/posts\/11389\/revisions"}],"predecessor-version":[{"id":11743,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/posts\/11389\/revisions\/11743"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/media\/11390"}],"wp:attachment":[{"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/media?parent=11389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/categories?post=11389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/leukemiarf.org\/wp-json\/wp\/v2\/tags?post=11389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}