{"id":11355,"date":"2022-02-03T10:23:27","date_gmt":"2022-02-03T16:23:27","guid":{"rendered":"https:\/\/leukemiarf.org\/?p=11355"},"modified":"2022-07-27T09:28:54","modified_gmt":"2022-07-27T14:28:54","slug":"two-patients-cancer-free-cart","status":"publish","type":"post","link":"https:\/\/leukemiarf.org\/news\/two-patients-cancer-free-cart\/","title":{"rendered":"Two Patients Still Cancer-Free Ten Years After CAR T-Cell Therapy"},"content":{"rendered":"\n
<\/div>\n\n\n\n

In 2010, two leukemia patients received an experimental immunotherapy called CAR T-cell therapy. Ten years later, the patients are in remission, suggesting a long-term therapy for leukemia \u2013 some researchers even describe it as a possible cure.<\/p>\n\n\n\n

CAR T-cell therapy uses the patients’ own genetically engineered immune cells to track down and destroy cancer cells. Based on the results of the study<\/a>, “we can now conclude that CAR T-cells can actually cure patients with leukemia,” cancer immunologist and study coauthor Carl June said at a February 1 news briefing.<\/p>\n\n\n\n

Doug Olsen was one of the patients. “From a patient’s viewpoint, when you’re told you’re pretty much out of options, the important thing is always to maintain hope. And certainly, I hoped this was going to work,” Olsen said at the news briefing.<\/p>\n\n\n\n

Olsen was diagnosed with chronic lymphocytic leukemia (CLL)<\/a> when he was 49. He underwent chemotherapy, putting him in remission for about five years before he experienced a rapid decline. By 2010, “about 50% of my bone marrow was CLL.”<\/p>\n\n\n\n

Olsen was given his first infusion of CAR T-cells in September of 2010. Shortly after, he began experiencing severe flu-like symptoms, a common side effect of the therapy. A week later, his oncologist told him that no cancer cells could be detected in his body.<\/p>\n\n\n\n

Doctors and researchers “don’t use words like ‘cure’ lightly or easily,” said oncologist and study coauthor David Porter. But with both patients remaining cancer-free and the CAR T-cells still on patrol and on surveillance for residual leukemia after a decade, the therapy has performed “beyond our wildest expectations.”<\/p>\n\n\n\n

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In 2010, two leukemia patients received an experimental immunotherapy called CAR T-cell therapy. 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