{"id":13362,"date":"2023-02-02T10:33:14","date_gmt":"2023-02-02T16:33:14","guid":{"rendered":"https:\/\/leukemiarf.org\/?page_id=13362"},"modified":"2024-04-25T09:21:04","modified_gmt":"2024-04-25T14:21:04","slug":"chronic-myelomonocytic-leukemia","status":"publish","type":"page","link":"https:\/\/leukemiarf.org\/leukemia\/chronic-myelomonocytic-leukemia\/","title":{"rendered":"Chronic Myelomonocytic Leukemia"},"content":{"rendered":"\n\n\t\tOn this page\n\t\t\t\t\t\n
Chronic myelomonocytic leukemia (CMML) is a rare blood cancer in which the bone marrow does not make white blood cells effectively. It mostly affects adults and rarely children.<\/p>\n
Chronic myelomonocytic leukemia (CMML) is a rare, slowly progressing blood cancer. “Myelo-” means “marrow,” referring to the bone marrow.<\/p>\n
A stem cell (blood-producing cell) in the bone marrow mutates (changes). \u00a0These changes happen after conception, meaning these mutations are not passed down from your parents.<\/p>\n
The change in the stem cell causes it to make too many blasts and monocytes. Blasts are immature blood cells that can become either red blood cells or different types of white blood cells. Monocytes are the largest white blood cells in the blood that fight infections. “Mono-” means one, and “cyte” means cell.<\/p>\n
Monocytes take up a lot of space in the bone marrow. The bone marrow struggles to make other blood cells (red blood cells, platelets, and other white blood cells).<\/p>\n
CMML shares features with two other types of disorders: myelodysplastic and myeloproliferative. Myelodysplastic refers to the inability (“dys”) of the bone marrow to make (“plastic”) mature, functional blood cells. Myeloproliferative refers to the bone marrow making too many blood cells – monocytes in this case.<\/p>\n
The WHO classifies CMML into two subtypes based on the number of white blood cells in the blood.<\/p>\n
The World Health Organization (WHO) also separates CMML into two subgroups based on the percentage of blast cells in the blood and bone marrow.<\/p>\n
The WHO removed CMML-0 (<2% in blood and <5% in bone marrow) from the subgroup list in 2022. It did not impact the prognosis.<\/p>\n
Mutations in the TET2 (50% of cases), RAS (30% of cases), SRSF2, ASXL1, and DNMT3A genes contribute to the development of CMML. Scientists do not know why these genetic changes occur.<\/p>\n
Risk factors include:<\/p>\n
People with CMML have a higher risk of their cancer transforming into acute myeloid leukemia. This happens when the number of blast cells in your blood increase above 20%.<\/p>\n
Signs and symptoms depend on which CMML subtype you have.<\/p>\n
Symptoms of the myelodysplastic subtype may include:<\/p>\n
Symptoms of the myeloproliferative subtype may include:<\/p>\n
Your doctor asks about your medical history and performs a thorough physical examination.<\/p>\n
Tests needed to diagnose CMML may include:<\/p>\n
Treatment depends on your age, CMML subtype, current symptoms, response to treatment, and general health.<\/p>\n
Treatment options for CMML include:<\/p>\n
Support can make a significant difference when you face a cancer diagnosis. You can connect with others who understand these challenges through our peer support<\/a><\/strong> programs. We offer an online support community and a mentoring program. We also have a directory of resources<\/strong><\/a> to help patients, families, and caregivers.<\/p>\n Do you have questions about clinical trials? On our new Clinical Trials Hub learn how clinical trials are developed or if they are right for you.\u00a0You can also use the new Search Tool to see if there is a current leukemia-focused trial you would qualify for.<\/p>\n\t\t\t\n\t\t\t\t\t\t\tLEARN MORE\n\t\t\t\t\t<\/a>\n On this page Chronic Myelomonocytic Leukemia Chronic myelomonocytic leukemia (CMML) is a rare blood cancer in which the bone marrow does not make white blood cells effectively. It mostly affects…<\/p>\n","protected":false},"author":10,"featured_media":13364,"parent":108,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[1],"tags":[],"yoast_head":"\n\n\t\tClinical Trials Hub: A resource for leukemia patients and caregivers\n\t<\/h2>\n\t
\n\t\tRead next\n\t<\/h2>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t
Coping with your diagnosis<\/h3>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t
Choosing a treatment provider<\/h3>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t
Getting a second opinion<\/h3>\n\n","protected":false},"excerpt":{"rendered":"