New Investigator Research Grant Program

Myeloproliferative neoplasms (MPNs) are chronic blood cancers characterized by the overproduction of myeloid cells and persistent inflammation. Although current treatments can relieve symptoms, they do not cure the disease or stop disease progression. As a result, MPNs represent a significant unmet medical need. Our research focuses on a protein called DCAF7, which we have found to be critical for the growth of mutant MPN cells. DCAF7 helps regulate inflammatory pathways by interacting with other proteins that control gene expression. By understanding how DCAF7 drives both abnormal cell growth and inflammation, we aim to uncover new therapeutic strategies that could more effectively treat MPNs.